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department of Biochemistry

Research

 

Research in the Department of Biochemistry is focused around three broad themes:

  • Membrane Signaling
    Areas under study include mechanisms underlying store-operated calcium entry, including structure and function of STIM/Orai proteins and TRPC channels, calcium-activated K+ channels, nuclear receptors, glutamate transporters and lipid membrane structure and organization. Experimental approaches include high-resolution fluorescence imaging of Ca2+ signals; confocal imaging; quantitative measurement of cellular O2 consumption and cellular metabolites; fluorescence spectroscopy; and a variety of state-of-the-art biochemical, genetic, and electrophysiological techniques.

 


Faculty:

Parkson Lee-Gau Chong, PhD

Tanya Ferguson, PhD

Kathleen M. Giangiacomo, PhD

Raymond Habas, PhD

Vladimir M. Kolenko, MD, PhD

Madesh Muniswamy, PhD

Brad Rothberg, PhD

Jonathan Soboloff , PhD

Dianne R. Soprano, PhD

Wannian Yang, PhD

 

  • Protein Structure and Function
    X-ray crystallography and NMR spectroscopy approaches are used to enable structural study of enzymes, regulatory proteins, receptors, and ion channels. Several faculty use these and other tools of structural biology, including molecular modelling and visualization, in conjunction with functional approaches that include pre-steady state and steady state kinetics, 1H, 15N and 31P NMR, hydrogen/deuterium exchange, electrophysiology of reconstituted ion channels, and protein modification through mutagenesis.

 


Faculty:

Mark Andrake, PhD

Kathleen M. Giangiacomo, PhD

Charles Grubmeyer, PhD

Dale Haines, PhD

Eileen Jaffe, PhD

Madesh Muniswamy, PhD

Heinrich Roder, PhD

Brad Rothberg, PhD

Jonathan Soboloff , PhD

 

  • Molecular Biology, Cellular Biology and Genetics
    Several faculty members are engaged in research on: cancer biology, antiviral mechanisms, cell cycle control, cell differentiation, control of gene expression, mitochondrial function, nuclear hormone receptors, DNA replication, DNA repair, mechanism of oncogene activation, tumor suppressors, and carcinogenesis. Model systems used in the this work include mammalian cell lines and transgenic animals.

 


Faculty:

Siddharth Balachandran, PhD
Margret Einarson, PhD

Greg H. Enders, MD, PhD

Nora Engel, PhD

Ana Gamero, PhD

Antonio Giordano, MD, PhD
Erica Golemis, PhD

Xavier Grana, PhD

Raymond Habas, PhD

Dale Haines, PhD

Barbara Hoffman, PhD

Vladimir M. Kolenko, MD, PhD

Keith Latham, PhD

Dan Liebermann, PhD

Madesh Muniswamy, PhD

Alana O’Reilly, PhD

Richard Pomerantz, PhD
Matthew Robinson, PhD

José Russo, MD, FACP

Jonathan Soboloff , PhD

Dianne R. Soprano, PhD

A. Raza Zaidi, PhD