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Independence Blue Cross Cardiovascular Research Center

INDEPENDENCE BLUE CROSS

cardiovascular research center

Research Programs

 

Our current research focuses on:

 
[Enter Research Focus Here]

 

Investigator: Arthur M. Feldman, MD, PhD

 

 

Signal Transduction Mechanisms of EGF Receptor

 

Investigator:  Satoru Eguchi, MD, PhD

 

 

Allograft Inflammatory Factor-1 Expression

 

Investigator:  Michael Autieri, PhD

 

The goal of this project is to determine the role and identity of the metalloprotese required for ErbB activation by angiotensin II in the vasculature.

 

 

Role of Membrane Shedding in Cardiac Myocyte Death

 

Investigator:  AbdelKarim Sabri, PhD

 

 

 

ErbB Activation via a Metalloprotease by Angiotensin

 

Investigator:  Satoru Eguchi, MD, PhD

 

The goal of this project is to determine the role and identity of the metalloprotese required for ErbB activation by angiotensin II in the vasculature.

 

 

 

Ca2+ Regulation in newly formed Ventricular Myocytes

 

Investigator:  Steven Houser, PhD

 

To define the respective roles of sarcoplasmic reticulum and sodium calcium exchanger Ca transport to dysfunctional contractility in hypertrophied/failing feline and human myocytes.

 

 

 

Contractility/Failing & Recovering Human Myocytes

 

Investigator:  Steven Houser, PhD

 

To establish reliable techniques for isolation of myocytes from human hearts and to characterize their basic physiological properties.

 

 

 

AIF-1 Expression i VSMC growth and arteriopathy

 

Investigator:  Michael Autieri, PhD

 

The specific aims are to determine the mechanisms responsible for AIF-1 growth enhancing properties in VSMC, determine AIF-1 protein-protein interactions, and determine if AIF-1 expression in endomyocardial biopsies is predective of cardiac allograft rejection and development of transplant arteriopathy.

 

 

 

Inflammatory proteases, sheddases & cardiomyocyte

 

Investigator:  AbdelKarim Sabri, PhD

 

The goals of this project are to determine the role of inflammatory proteases on cardiac remodeling in response to volume overload induced cardiac hypertrophy and failure.

 

 

 

Sex-based differences in post-infraction remodel

 

Investigator:  Deborah Crabbe, MD

 

 

Mechano-chemical signaling in endolethial cell

 

Investigator:  Victor Rizzo, PhD

 

The major goal of this project is determine the molecular properties through which caveolae participate in the mechanotransduction process. 

 

 

 

Mechanisms improved diastolic function Human Heart

 

Investigator:  Steven Houser, PhD

 

To define the role of abnormal Ca regulation in diastolic dysfunction in failing human ventricular myocytes.

 

 

 

Analysis congestive Heart failure North Philadelphia POP

 

Investigator:  Alfred Bove, MD

 

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Preventing Heart Disease in underderserved patients

 

Investigator:  Alfred A. Bove, MD

 

Our current medical system is designed to address acute episodic care.  Chronic disease management, which requires consistent application and frequent monitoring of patient status, is problematic and inconsistent. According to the Institute of Medicine, a disconnect exists between the availability of comprehensive chronic disease management programs and their effective utilization – a real chasm. Especially in underserved populations, lack of surveillance and risk assessment allows these conditions to persist until an actual event occurs (heart attack, new angina or sudden death, stroke). Our objective is to develop and test new innovative approaches to address the goals of Healthy People 2010 and close this chasm in a proactive fashion.

 

 

 

Sex-based differences in aldosterone antagonism

 

Investigator:  Deborah Crabbe, MD

 

My research interests are centered on understanding the role of sex-related differences in the pathophysiology of left ventricular dysfunction. I have recently received a Minority Institution Research Scientist Development Award (KO1: Dr. Houser serving as the Mentor) to specifically investigate the role of the renin-angiotensin system and estrogen status on LV remodeling after myocardial infarction.

 

 

Human Cardiac Stem/Progenitor Cells

 

Investigator:  Steven Houser, PhD