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John W. Muschamp, PhD

 

Assistant Professor, Pharmacology

Assistant Professor, Center for Substance Abuse Research

Telephone:  215-707-8089

Email: john.muschamp@temple.edu

 

Department of Pharmacology

Center for Substance Abuse Research

 

Educational Background:

 

BA, Psychology, Gettysburg College, Gettysburg, PA, 2001

 

MA, Behavioral Neuroscience, University at Buffalo, SUNY, Amherst, NY, 2005

 

PhD, Neuroscience, Florida State University, Tallahassee, FL, 2007

 

Postdoctoral Fellowship, Neuroscience, Harvard Medical School, Belmont, MA, 2011

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Research Interests

 

muschamp research

Dr. Muschamp's laboratory studies the neurobiology of motivation, affect, and executive function and how they are altered in psychiatric disorders like drug addiction. To model these psychological constructs in animals we use a number of behavioral paradigms like intracranial self-stimulation (ICSS), place conditioning (CPP), and the 5-choice serial reaction time task (5CSRTT). To understand part of the neurocircuitry that is common to these different behaviors (i.e. the mesolimbic dopamine pathway), we have used in vivo microdialysis, electrophysiology, viral-mediated gene transfer, and a variety of neuroanatomical techniques. Important modulators of mesolimbic dopamine transmission are hypocretin (orexin) and dynorphin peptides released by projections from the hypothalamus. We have demonstrated that the hypocretin system is an essential integrator of reward-relevant information that potently excites the midbrain dopamine reward pathway. We have also shown that attenuated hypocretin signaling decreases the reinforcing effects of cocaine, rewarding lateral hypothalamic electrical stimulation, and natural rewards like sex behavior. Additionally, we have also established that decreased hypocretin transmission attenuates spontaneous- and cocaine-induced impulsive behavior. These effects appear to arise from the ability of hypocretin to modulate the aversive or depressive-like effects of hypocretin's cotransmitter dynorphin. Understanding the relationship and interactions between hypocretin and dynorphin is a major goal of our research. Because disturbances in mood, motivation, and executive function often accompany addiction and other psychiatric illnesses (e.g. bipolar disorder), and may be mediated by disrupted function of the hypocretin-dynorphin system, our work is designed to determine the utility of hypocretin receptor antagonists for the treatment of substance use disorders or other psychiatric illnesses characterized by high levels of impulsivity.


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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24706819. Muschamp JW, Hollander JA, Thompson JL, Voren G, Hassinger LC, Onvani S, Kamenecka TM, Borgland SL, Kenny PJ, Carlezon WA Jr, Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area. Proc Natl Acad Sci U S A :()2014 Mar 24

24641197. Baimel C, Bartlett SE, Chiou LC, Lawrence AJ, Muschamp JW, Patkar O, Tung LW, Borgland SL, Orexin/hypocretin role in reward: implications for opioid and other addictions. Br J Pharmacol :()2014 Feb 15

24495460. Donahue RJ, Muschamp JW, Russo SJ, Nestler EJ, Carlezon WA Jr, Effects of Striatal ?FosB Overexpression and Ketamine on Social Defeat Stress-Induced Anhedonia in Mice. Biol Psychiatry :()2014 Jan 8

23293139. Muschamp JW, Carlezon WA Jr, Roles of nucleus accumbens CREB and dynorphin in dysregulation of motivation. Cold Spring Harb Perspect Med 3:2(a012005)2013 Feb 1

23269344. Carey AN, Liu X, Mintzopoulos D, Paris JJ, Muschamp JW, McLaughlin JP, Kaufman MJ, Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions. Prog Neuropsychopharmacol Biol Psychiatry 43:(49-54)2013 Jun 3

22763624. Reynolds LM, Engin E, Tantillo G, Lau HM, Muschamp JW, Carlezon WA Jr, Rudolph U, Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward. Neuropsychopharmacology 37:11(2531-40)2012 Oct

21962331. Muschamp JW, Nemeth CL, Robison AJ, Nestler EJ, Carlezon WA Jr, ?FosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. Biol Psychiatry 71:1(44-50)2012 Jan 1

21835335. Muschamp JW, Van't Veer A, Carlezon WA Jr, Tracking down the molecular substrates of stress: new roles for p38a MAPK and kappa-opioid receptors. Neuron 71:3(383-5)2011 Aug 11

21531393. Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA Jr, Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry 70:5(425-33)2011 Sep 1

21414930. Muschamp JW, Van't Veer A, Parsegian A, Gallo MS, Chen M, Neve RL, Meloni EG, Carlezon WA Jr, Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats. J Neurosci 31:8(3095-103)2011 Feb 23

17933463. Muschamp JW, Hull EM, Melanin concentrating hormone and estrogen receptor-alpha are coexstensive but not coexpressed in cells of male rat hypothalamus. Neurosci Lett 427:3(123-6)2007 Nov 12

17360905. Muschamp JW, Dominguez JM, Sato SM, Shen RY, Hull EM, A role for hypocretin (orexin) in male sexual behavior. J Neurosci 27:11(2837-45)2007 Mar 14

15598140. Lagoda G, Muschamp JW, Vigdorchik A, Hull EM, A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats. Behav Neurosci 118:6(1317-23)2004 Dec

15488546. Hull EM, Muschamp JW, Sato S, Dopamine and serotonin: influences on male sexual behavior. Physiol Behav 83:2(291-307)2004 Nov 15

15364028. Muschamp JW, Regina MJ, Hull EM, Winter JC, Rabin RA, Lysergic acid diethylamide and [-]-2,5-dimethoxy-4-methylamphetamine increase extracellular glutamate in rat prefrontal cortex. Brain Res 1023:1(134-40)2004 Oct 8

15051159. Dominguez JM, Muschamp JW, Schmich JM, Hull EM, Nitric oxide mediates glutamate-evoked dopamine release in the medial preoptic area. Neuroscience 125:1(203-10)2004

12213529. Muschamp JW, Siviy SM, Behavioral sensitization to amphetamine follows chronic administration of the CB1 agonist WIN 55,212-2 in Lewis rats. Pharmacol Biochem Behav 73:4(835-42)2002 Nov

11170017. Muschamp JW, Fong PP, Effects of the serotonin receptor ligand methiothepin on reproductive behavior of the freshwater snail Biomphalaria glabrata: reduction of egg laying and induction of penile erection. J Exp Zool 289:3(202-7)2001 Feb 15

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